Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma: The CheckMate 143 Phase 3 Randomized Clinical Trial

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Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma: The CheckMate 143 Phase 3 Randomized Clinical Trial

#Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma: The CheckMate 143 Phase 3 Randomized Clinical Trial| 来源: 网络整理| 查看: 265

Conflict of Interest Disclosures: Dr Reardon has received grant funding from Acerta Pharmaceuticals, Incyte, Midatech, Omniox, and Tragara; grant funding and personal fees from Agenus, Celldex, EMD Serono, and Inovio; and personal fees from Advantagene, Genentech/Roche, Merck, Merck KGaA, Monteris, Novocure, Oncorus, Oxigene, Regeneron, Stemline Therapeutics, and Taiho Oncology. Dr Brandes has received travel grants from Roche and Celgene. Dr Omuro has received personal fees from Bristol Myers Squibb, BTG, AstraZeneca, Inovio, Merck, Stemline, Novocure, and Alexion. Dr Mulholland has received grant funding, travel support, and nonfinancial support (to forward plan immuno-oncology use at Mount Vernon) from Bristol Myers Squibb. Dr Lim has received grant funding from Bristol Myers Squibb, Kryin-Kwoya, Biohaven, Accuary, and Arbor; personal fees for an advisory board from SQZ Biotechnologies, VBI Technologies, and Tocagen; consultancy fees from Stryker and Baxter; and grant funding for laboratory research from DNATrix; and has a patent combining local chemotherapy with immunotherapy pending to Arbor and a patent combining stereotactic radiosurgery with immunotherapy that has been issued. Dr Baehring has served as a consultant to Bristol Myers Squibb. Dr Ahluwalia has received research funding from Bristol Myers Squibb; grants and consultancy fees from Incyte, Bristol Myers Squibb, AstraZeneca, Novocure, and AbbVie; grant funding from Tracon, Novartis, Pharmacyclics, Merck, and Bayer; consultancy fees from Monteris Medical, Caris Life Sciences, MRI Solutions, CBT Pharmaceuticals, Flatiron, Karyopharm, Tocagen, Bayer, and Varian Medical Systems; personal fees from Kadman and VBI vaccines; stock options from MimiVax and Doctible; and personal fees from Forma Therapeutics outside the submitted work. Dr Roth has received personal fees from Bristol Myers Squibb, Covagen, Medac, Novocure, Roche, Debiopharm, and Virometix; grants from MSD outside the submitted work. Dr Bähr has received research funding and personal fees from Bristol Myers Squibb and personal fees from Novocure and Medac. Dr Phuphanich reported grants from Bristol Myers during the conduct of the study. Dr Sepulveda has received personal fees from Bayer, AbbVie, Novartis, GW Pharma, Celgene, and Pierre Fabre; and grant funding and personal fees from Pfizer and Catalysis Pharma. Dr De Souza reported other from BioSceptre outside the submitted work. Dr Sahebjam has received grant funding from Merck and Bristol Myers Squibb and funding from Bristol Myers Squibb, Merck, Brooklyn ImmunoTherapeutics, Lilly Pharmaceuticals, Cortice Bioscience, Merck, and Bristol Myers Squibb outside the submitted work. Drs Carleton, Tatsuoka, and Taitt are employed by Bristol Myers Squibb. Dr Zwirtes is employed by and owns stock in Bristol Myers Squibb. Dr Sampson has served as a consultant/advisory board member for Bristol Myers Squibb and Brainlab; has received grant funding and personal fees from and is a patent holder for Celldex Therapeutics; has received grant funding and personal fees from, owns equity/stock in, and is a patent holder for Annias Immunotherapeutics; and owns stock in Istari. Dr Weller has received fees for patient enrollment per study contract from Bristol Myers Squibb; grant funding and personal fees from AbbVie, MSD, Novocure, Merck (EMD Serono), and Roche; grant funding from Actelion, Acceleron, Bayer, Tragara, OGD Pharma, Piqur, and Dracen; and personal fees from Basilea, Celgene, Celldex, Progenics, Tocagen, and Orbus.



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